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Tramadol is powerful on two fronts: About 20 percent of its painkilling impacts originate from opioids, and 80 percent from fixings that repress the reuptake of serotonin and norepinephrine, two chemicals in the mind related with temperament and responsiveness to torment, said Dr. Lewis Nelson, a teacher of crisis solution at New York University's Langone Medical Center. Nonetheless, tramadol's opioid and serotonergic impacts are essential since they permit tramadol to treat both pain and the mental components of pain, he said.
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