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2-Chloro-5-nitropyridine CAS 4548-45-2 : A Highly Reactive Key Heterocyclic Intermediate | |
Free Online Advertising Free Internet Web Site Advertising. UK Free Classifieds United Kingdom Free Ads Website. 100% Free Ad Posting. Canada Free Ads Popular Online Classifieds in Canada. No Sign up, No Email Required to Post. 2-Chloro-5-nitropyridine (CAS: 4548-45-2) is a chlorinated and nitrated pyridine derivative widely used in pharmaceuticals, agrochemicals, and fine chemical synthesis. Its structure features a pyridine ring bearing two strong electron-withdrawing groups: the nitro group at the 5-position significantly increases electron deficiency, while the chlorine at the 2-position provides an excellent leaving group for nucleophilic substitution. This unique electronic environment makes the compound an ideal starting material for building diverse heterocyclic structures. In synthetic chemistry, 2-Chloro-5-nitropyridine reacts efficiently with amines, thiols, alcohols and other nucleophiles via SNAr pathways to generate a variety of substituted pyridines, which are frequently used in the development of pharmaceutically active scaffolds. Reduction of the nitro group yields the corresponding aminopyridine, an important intermediate in numerous API routes. It is commonly applied in the preparation of kinase inhibitors, anti-inflammatory candidates, and antiviral molecules containing pyridine frameworks. In the agrochemical field, its structural tunability makes it valuable for synthesizing heterocyclic fragments found in herbicides, fungicides, and plant growth regulators. The nitro-enhanced electron-deficient nature improves reaction efficiency and contributes to strong biological activity in the final products, making it a core intermediate in several classical agrochemical pathways. With excellent reaction compatibility, 2-Chloro-5-nitropyridine readily participates in cross-coupling, addition, and multistep cascade reactions, supporting both laboratory synthesis and industrial-scale production. Its good stability and ease of storage make it a dependable building block for research and manufacturing. As a specialized fine chemical supplier, UCHEM provides 2-Chloro-5-nitropyridine (CAS: 4548-45-2) in stock or on a custom basis. We offer mature, stable production routes with strict batch-to-batch consistency. Flexible packaging, fast delivery, and technical support further enable smooth progress from research to commercialization, delivering stable, cost-effective, and fully traceable raw materials. | |
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2025-11-26 (0.506 sec)