High-Purity 2,4-Dimethoxybenzylamine (CAS 20781-20-8) (Shopping - Other Shopping Ads)

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High-Purity 2,4-Dimethoxybenzylamine (CAS 20781-20-8)
2,4-Dimethoxybenzylamine (CAS: 20781-20-8) is a versatile intermediate that can be conveniently prepared by reducing 2,4-dimethoxybenzonitrile using NaBH₄ and BF₃·OEt₂ in THF. This aromatic amine serves as a valuable nucleophile in synthetic organic chemistry, enabling a broad range of transformations. It has been employed in studies on the 1,4-reactivity of 5-bromo-2-indene-1-one and as an ammonia equivalent in the efficient synthesis of 2,4,5-trisubstituted oxazoles via a tandem Ugi/Robinson-Gabriel sequence. Additionally, it plays a key role in the total synthesis of (-)-muraymycin D2 and its epimer—potent antibacterial nucleoside natural products. Applications also include the two-step Ugi synthesis of amide derivatives of uracil polyoxin C methyl ester, the preparation of N-hydroxythiourea, and the synthesis of anti-HIV-1 agents. With its broad utility in pharmaceutical and fine chemical research, 2,4-Dimethoxybenzylamine is an indispensable building block for medicinal chemistry innovation.
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2025-08-19 (0.482 sec)